Calcitonin gene related peptide (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms, α-CGRP and β-CGRP. α-CGRP is a 37 amino acid peptide and is formed from the alternative splicing of the calcitonin/CGRP gene located on chromosome 11. CGRP is one of the most abundant peptides produced in both peripheral and central neurons.It is the most potent peptide vasodilator and can function in the transmission of pain.In the trigeminal vascular system the cell bodies on the [trigeminal ganglion] are the main source of CGRP. CGRP is thought to play a role in cardiovascular homeostasis and nociception. CGRP mediates its effects though a heteromeric receptor composed of a G protein-coupled receptor called calcitonin receptor-like receptor (CLR) and a receptor activity-modifying protein (RAMP1). CGRP receptors are found throughout the body suggesting that the protein may modulate a variety of physiological functions in all major systems.Increased levels of CGRP have been reported in migraine and Temporomandibular joint disorder patients as well as a variety of other diseases such as cardiac failure, hypertension, and sepsis.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.