Serine/threonine-protein kinase B-Raf or simply B-Raf, also known as proto-oncogene B-Raf or v-Raf murine sarcoma viral oncogene homolog B1, is a protein that in humans is encoded by the BRAF gene.The B-Raf protein is involved in sending signals in cells and in cell growth.
The BRAF gene may be mutated and as a consequence, the normal functioning of the B-Raf protein may be altered.Certain inherited BRAF mutations cause birth defects. Alternatively, other acquired mutations (oncogene) in adults may cause cancer. Drugs that treat those cancers by inhibiting B-Raf are being studied, and one, PLX4032, has started phase III clinical trials.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.