This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one ofwhich was initially identified as a MYC-interacting protein with features of a tumorsuppressor. Isoforms that are expressed in the central nervous system may be involvedin synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin,and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoformslocalize to the cytoplasm and nucleus and activate a caspase independent apoptoticprocess. Studies in mouse suggest that this gene plays an important role in cardiacmuscle development. Alternate splicing of the gene results in ten transcript variantsencoding different isoforms. Aberrant splice variants expressed in tumor cell lines havealso been described. Alternate Names: anti-BIN1 antibody, anti-bridging integrator 1 antibody, anti-AMPH2 antibody,anti-AMPHL antibody, anti-DKFZp547F068 antibody, anti-MGC10367 antibody,anti-SH3P9 antibody, anti-amphiphysin II antibody, anti-amphiphysin-like antibody,anti-box dependant MYC interacting protein 1 antibody.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.