AQP2 is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular vesicles located throughout the cell.
Mutations in this channel are associated with nephrogenic diabetes insipidus, which can be either X-linked recessive, or autosomal dominant/recessive.
Lithium, which is often used to treat bipolar disorder, can cause acquired diabetes insipidus by decreasing the expression of the AQP2 gene. This can result in debilitating increases in the rate of urine production.
The expression of the AQP2 gene is increased during conditions associated with water retention such as pregnancy and congestive heart failure.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.