BRCA1 (breast cancer 1, early onset) is a human tumor suppressor gene, which produces a protein, called breast cancer type 1 susceptibility protein.
BRCA1 is expressed in the cells of breast and other tissue, where it helps repair damaged DNA, and destroy the cell when DNA can't be repaired. If BRCA1 itself is damaged, the damaged DNA can let the cell duplicate without control, and turn into a cancer.
The protein encoded by the BRCA1 gene combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). The BRCA1 protein associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks ubiquitination, transcriptional regulation as well as other functions.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.