Collagen type IV is a major component of basement membranes, such as those associated with capillaries and within glomeruli. It is composed of α1(IV) chain and α2(IV) chain in 2:1 ratio. It is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. It can form insoluble fibers with high tensile strength. Collagen IV is useful in detecting the loss of parts of basement membranes in carcinomas.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.