Human corticotropin-releasing factor (hCRF) is a naturally occurring 41 residue neuropeptide produced in the hypothalamus and mainly responsible for stimulating the hypothalamic-pituitary-adrenal (HPA) axis. However, this neurohormone also appears to possess strong anti-edema properties independent of adrenal gland function, perhaps acting directly on brain and tumor blood vessels or surrounding epithelial tissue. Therefore, hCRF has been proposed as an alternative treatment for peritumoral brain edema that might provide substantial benefits with fewer side effects than corticosteroids.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.