The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene.
CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications, as exemplified by the ability of sialyfucosylated glycoforms of CD44 to bind P-, L-, and E-selectin under shear flow conditions.CD44 glycosylation also directly controls its binding capacity to fibrin and immobilized fibrinogen. Furthermore, specialized sialofucosylated glycoform of CD44 called HCELL is found natively on human hematopoietic stem cells, and is a highly potent E-selectin and L-selectin ligand. HCELL functions as a "bone homing receptor", directing migration of human hematopoietic stem cells and mesenchymal stem cells to bone marrow.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.