Cyclin C is a highly conserved protein that is involved in both the positive and negative regulation of transcription in all eukaryotes from yeast to humans. This function is accomplished in cooperation with cyclin-dependent kinases (CDKs). The primary kinase partner for cyclin C is the kinase Cdk8. Cyclin C regulates the substrate specificity and kinase activity of this protein, and has also been shown to bind to Cdk3. Cyclin C, in conjunction with Cdk3 kinase, promotes retinoblastoma protein (pRb)-dependent exit from the quiescent state of the cell cycle. Kinase-independent roles for cyclin C have also been described. These roles include the ability to promote the cellular proliferation of a murine pro-B-cell line, BAF-BO3, and mediate the homotypic cell adhesion of these cells in association with c-Myc.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.