Cholecystokinin fragment for Sale
Cholecystokinin fragment is used in research on biochemical ,medcine.
Active immunization of white rats with cholecystokinin-4 covalently linked to the antigen carrier BSA evoked long-lasting changes in the rats' behavior, which were in the opposite direction to the anxiogenic effects of cholecystokinin-4 itself, showing that immunization had anxiolytic effects. Molecular weight: 1143.27.
Cholecystokinin fragment exhibits low solubility in water. We recommend dissolving initially in ammonium hydroxide and diluting with water or buffer to the desired concentration. Appearance: solid. Molecular formula: C49H62N10O16S3. Full interaction with brain CCK8 receptors could require both the sulfate group and the maintening of conformational constraints.
Cholecystokinin plays a key role in facilitating digestion within the small intestine. Sequence: Asp-Tyr-(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2. It is secreted from mucosal epithelial cells in the first segment of the small intestine (duodenum), and stimulates delivery into the small intestine of digestive enzymes from the pancreas and bile from the gallbladder.
Cholecystokinin is also produced by neurons in the enteric nervous system, and is widely and abundantly distributed in the brain. Storage: preserve in a sealed dry filling argon place,the temperature below 0℃. Immunoenzyme analysis demonstrated the presence of antibodies to cholecystokinin-4 in the serum of immunized rats. Brytningsindeks 1.643. These data are interesting from the point of view of correcting pathological anxiety and fear states by inverse immunoregulation. Moreover, the N-terminal part of CCK7 forms a C7 structure with a weak H-bond between the CO of Gly and the NH of Trp. In this model all CCK7 hydrophobic side chains are in close vicinity, far from the hydrophilic sulfate group.