What is Ceftriaxone?

Ceftriaxone is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. In most cases, it is considered to be equivalent to cefotaxime in terms of safety and efficacy. Ceftriaxone sodium is marketed by Hoffman-La Roche under the trade name Rocephin.
Ceftriaxone is generally acclimated (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the analysis of community-acquired or balmy to abstinent bloom care-associated pneumonia. It is aswell a best biologic for analysis of bacterial meningitis. In pediatrics, it is frequently acclimated in delirious breed amid 4 and 8 weeks of age who are accepted to the hospital to exclude sepsis. The dosage for astute ear infection in the actual adolescent is 50 mg/kg IM, one dosage only. It has aswell been acclimated in the analysis of Lyme disease, typhoid agitation and gonorrhea.
Intravenous dosages may be adapted for physique accumulation in adolescent patients and is administered every 12–24 hours, at a dosage that depends on the blazon and severity of the infection.
For the analysis of gonorrhea, a individual intramuscular bang is usually given. According to the Journal of Family Practice, Volume 60, NO 12, December 2011; the intramuscular dosage of ceftriaxone (Rocephin) has been added from 125mg IM to 250mg IM due to accretion attrition of the gonococcal bacteria. It is aswell recommended that 1000mg of azithromycin be accustomed orally at the aforementioned time for bifold treatment. This aswell takes affliction of analysis of basal chlamydia back analysis for chlamydia infection is aswell recommended. It accept to not be alloyed or administered accompanying (within 48 hours) with calcium-containing solutions or articles for patients adolescent than 28 canicule old, even via altered beverage curve (rare baleful cases of calcium-ceftriaxone precipitates in lung and kidneys in neonates accept been described).
To abate the affliction of intramuscular injection, ceftriaxone may be reconstituted with 1% lidocaine.
Ceftriaxone has aswell been advised for ability in preventing backsliding to cocaine addiction.
Chemistry
Ceftriaxone is a white apparent crumb which is readily acrid in water, sparingly acrid in booze and actual hardly acrid in ethanol. The pH of a 1% aqueous band-aid is about 6.7.
The syn-configuration of the methoxyimino atom confers adherence to β-lactamase enzymes produced by abounding Gram-negative bacteria. Such adherence to β-lactamases increases the action of Ceftriaxone adjoin contrarily aggressive Gram-negative bacteria. In abode of the calmly hydrolysed acetyl accumulation of cefotaxime, ceftriaxone has a metabolically abiding thiotriazinedione moiety.