What is Muramyl dipeptide?
Muramyl dipeptide (MDP) is a constructed immunoreactive peptide consisting of N-acetyl muramic acerbic absorbed to a abbreviate amino acerbic alternation of L-Ala-D-isoGln. It was aboriginal articular in bacterial corpuscle bank peptidoglycan as an alive basic in Freund’s complete adjuvant. In the cell, MDP is detected by NOD2, a cytoplasmic receptor acceptance to the animal congenital allowed system. NOD2 mutations are frequently empiric in patients with Crohn’s disease, an autoimmune disorder, suggesting the acceptation of the MDP-NOD2 alleyway in activating immunity. For this reason, structural modifications of MDP and its derivatives accept been abundantly advised in an attack to access accessory activity and addition the allowed acknowledgment finer for analytic use in the analysis of blight and added diseases. This analysis summarizes the constructed allure of MDP and its derivatives and discusses their pharmacological activity and stereoselective synthesis.