Synonym: 8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one Appearance:Yellow Powder Purity:99.80 % DMSO Solubility: 86 mg/mL (206.54 mM) Function:
1.Various pharmacological functions including antioxidant, anti-inflammatory and antiapoptotic.
2.Enhances superoxide dismutase activity.
3.Neuroprotective and anti-ischaemic effects in vivo. Description About Puerarin CAS 3681-99-0:
Puerarin is a 5-HT2C receptor and a benzodiazepine site antagonist ,which is an isoflavone found in the roots of Pueraria.In China, Pueraria is clinically used to treat cardiovascular disease. Another study shows that Pueraria also has anti-cancer properties. Puerarin dose-dependently reduced HT-29 cell growth at 25 μM with an increase in bax and a decrease in c-myc and bcl-2.
It is biotransformed by intestinal bacteria to give the phytoestrogens daidzein and equol , resulting in antithrombotic, antiallergic, and other salutary effects. When given intraperitoneally, puerarin evokes diverse responses by modulating serotonin receptors. This compound also suppresses lipopolysaccharide-mediated activation of NF-κB in RAW 264.6 macrophages when given at 20-40 μM.