Anti-SYVN1(synovial apoptosis inhibitor 1) hu、 rat、 mo、 cattle

Description:
SYVN1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of SYVN1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. SYVN1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. SYVN1 contains one ring-type zinc finger.

Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.