Anti-TRF1（telomere repeat binding factor1）

Description:
TRF1 (Telomere Repeat-Binding Factor 1), which is also known as TERF1, plays a role in the negative regulation of telomere length. It binds to the telomeric double-stranded TTAGGG repeat, and is a component of the shelterin complex, also known as the telosome. Shelterin associates with, and protects, telomere ends. In the absence of this activity, telomeres are accessible to the DNA damage surveillance machinery, and chromosome ends are inappropriately processed by DNA repair pathways. TRF1 is phosphorylated on S219 in an ATM-dependent manner in response to ionising DNA damage. TRF1 is also ADP-ribosylated by TNKS1 and TNKS2; this reduces the ability of TRF1 to bind to telomeric DNA.

Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.