Anti-P-AKT1/PKB1/2/3（Thr473）

Description:
The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trkgp140, that serves as a receptor for certain neurotrophic factors, including nerve growthfactor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related toTrk A. Trk B expression is confined to tissues within the central and peripheral nervoussystems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, caninduce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encodedby Trk B, although BDNF elicits a response at least two orders of magnitude greaterthan NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor forBDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodesa protein designated Trk C gp145 that is preferentially expressed in brain tissue, isequally related to Trk A and Trk B and is a functional receptor for NT-3.

Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.