Anti-CD272/BTLA(B and T lymphocyte attenuator)

Description:
CD272 is a lymphocyte inhibitory receptor. It is a third member of co-inhibitory receptors of the CD28 immunoglobulin superfamily with similarities to (CTLA)-4 and (PD)-1 and interacts with a B7 homolog, B7H4. CD272 is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells but not Th2 cells. CD272 is a unique co-receptor which interacts with the tumor necrosis factor receptor superfamily member herpesvirus entry mediator (HVEM) and this interaction is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response and might also play an important role in the maintenance of T cell tolerance.

Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.