Anti-CCR-4(CC chemokine receptor 4)

Description:
Receptors for the C - C chemokine family include CCR1, CCR2A, CCR3, CCR4, CCR5 and the Duffy blood group antigen. The C - C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR4 is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine.

Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.