Anti-Caspase-8 (pro Mch5)

Description:
Caspase 8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase 3. CASP8 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds.
The CASP8 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits.

Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.