Anti-B7-H1/PDL1/CD274(programmed death ligand 1)

Description:
CD274 (Cluster of Differentiation 274) also known as PD-L1 (Programmed Death Ligand-1) or B7-H1 is a protein which in humans is encoded by the CD274 gene.
It appears that upregulation of B7-H1 is a mechanism that cancers can employ to evade the host immune system. 
B7-H1 acts as a positive costimulatory molecule in intracellular infection.
In humans, PD-L1 was found to have altered expression in pediatric patients with Systemic lupus erythematosus. Studying isolated PBMC from healthy children, immature myeloid dendritic cells and monocytes expressed little PD-L1 at initial isolation, but spontaneously up-regulated PD-L1 by 24 hours. In contrast, both mDC and monocytes from patients with active SLE failed to upregulate PD-L1 over a 5 day time course, expressing this protein only during disease remissions. This may be one mechanism whereby peripheral tolerance is lost in SLE.

Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.