Anti-PTGS2 (Prostaglandin-endoperoxide synthase-2)

Description:
Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme which in humans is encoded by the PTGS2 gene.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase (COX), is the key enzyme in biosynthesis of the prostanoids, (prostaglandins, prostacyclin and thromboxanes.) It acts both as a dioxygenase and as a peroxidase. There are two isozymes of COX: a constitutive COX-1 and an inducible COX-2 (this enzyme), which differ in their regulation of expression and tissue distribution. COX-2 shows 86% - 89% amino acid sequence identity with mouse, rat, sheep, bovine, horse and rabbit COX-2 proteins, respectively. Human COX-2 is expressed in a limited number of cell types and regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.

Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.