PDGF-B ELISA kit

Storage Instruction:Store the kit at 4°C.
Description:
PDGF is synthesized mainly by megakaryocytes. It is stored in the alpha granules of platelets from which it is released after cell activation of platelets for example by thrombin. There are two types of polypeptide, A (16 kDa, 124 amino acids) and B (14 kDa, 140 amino acids), with about 50% sequence identity, disulfide linked into three possible dimeric molecules, PDGF-AA, -AB and –BB. PDGF binds to several plasma proteins and also to proteins of the extracellular matrix. In the adult organism PDGF is involved in wound healing processes. The aberrant expression of PDGF is observed with vascular proliferative diseases such as atherosclerosis. PDGF and PDGF-like factors are autocrine growth factor for meningiomas.