uPA-R ELISA Kit

Storage Instruction:Store the kit at 4°C.
Description:
Urokinase-type plasminogen activator receptor (uPAR) is linked to the cell membrane via a glycosylphosphatidylinositol anchor attached to the C-terminal hydrophobic domain . Both single chain pro-uPA and two-chain uPA bind to the NHbound by uPA, uPAR plays a major role in local proteolytic processes, thus facilitating cell migration as may occur during angiogenesis , neointima and atherosclerotic plaque formation ,and tumor cell invasion . uPAR may be a multifunctional receptor, not only promoting pericellular proteolysis but also involved in integrin-mediated cell adhesion and migration .uPAR has also been implicated in intracellular signaling, cellular differentiation, growth and  chemotaxis.  The expression of both u-PA and uPAR is increased in human atherosclerotic plaque and arterial aneurysms.