IL 1Ra ELISA Kit

Storage Instruction:Store the kit at 4°C.
Description:
IL-1ra binds to the IL-1 receptor Type II with considerably lower affinity than that shown by  IL-1β. This makes sense teleologically in that two mechanisms designed to inhibit the actions of IL-1βdo not compete with each other. Cells known to produce IL-1ra include monocytes, neutrophils, macrophages and fibroblasts. Cytokines known to upregulate IL-1ra production include IL-13, IL-6, IL-4, IFN-γ, GM-CSF and TGF-β, the latter apparently by triggering IL-1 production which itself triggers IL-1ra synthesis. The amino acid sequences of IL-1ra from at least four species have been determined (human, rat, mouse and rabbit) and found to be at least 75% homologous. IL-1ra can also be synthesized as a strictly intracellular form whose production is the result of an alternative splicing of exon 1.