Storage Instruction:Store the kit at 4°C. Description:
Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) is a 130kDa glycoprotein and member of the immunoglobulin superfamily, which is expressed on many haematopoietic and endothelial cells. PECAM-1 is expressed on the surface of various cells of the haematopoietic lineage, however the function of PECAM-1, if any, on haematopoietic progenitor cells and the bone marrow vasculature remains to be fully elucidated. It has been observed that expression of PECAM-1 decreases following the emigration of CD34+ cells and monocytes from the bone marrow to the blood. The expression of PECAM-1 on CD34+ cells, like that on endothelial cells, has been demonstrated to provide an anti-apoptotic signal, with ligation of PECAM-1 enhancing VLA-4 mediated adhesion, and blocking antibodies to PECAM-1 reducing transendothelial migration.