BCL-2 ELISA Kit

Storage Instruction:Store the kit at 4°C.
Description:
Bcl-2 initiates a new gene family involved in the regulation of cell death  and survival without affecting cell proliferation. This precise regulation 
and maintenance of balance between cell proliferation and cell death in  multicellular organisms is critical for tissue homeostasis. Bcl-2, encoded 
by a proto-oncogene, is an intracellular membrane-associated protein  that functions to block programmed cell death. Expression of Bcl-2 has 
been reported in a wide range of hematopoietic cells, nonneoplastic epithelia and epithelial malignancies. Bcl-2 levels are low or  undetectable in endothelial cells. 
The Bcl-2 gene has a unique function among mammalian oncogenes as  a negative regulator of apoptosis. It was first discovered because of its 
involvement in chromosomal translocations commonly found in  lymphomas . Bcl-2 is furthermore associated with stem cells committed  to differentiation and morphogenesis.