GMP-140 ELISA Kit

Storage Instruction:Store the kit at 4°C.
Description:
GMP-140, also known as CD62 or PADGEM , is a 140 kDa integral membrane glycoprotein functionally categorized as a member of the LEC-CAM family (lectinepidermal growth factor-complement binding cell adhesion molecules), or the selectin family. In non-activated conditions, GMP-140 is present in the alpha-granules of platelets or in the Weibel Palade bodies of endothelial cells . However, when activated by stimulators such as thrombin or by inflammatory or hemostatic mediators during intravascular inflammation, GMP-140 is rapidly secreted to the plasma membrane to promote adhesion of cells to vascular endothelia or to neutrophils and monocytes at the site of tissue injury . Previous studies suggested that GMP-140 is indeed a useful marker of platelet and endothelium activation in experimental inflammation models, and potentially in clinical situations. GMP-140 is also known to interact with leukocytes by a Ca2+ dependent lectin-like mechanism. GMP-140 has recently been cloned from endothilia and is found to be highly homologous to two other LEC-CAM adhesion molecules, ELAM-1 and the Mel-14 antigen, both of which are involved in various aspects of leukocyte adhesion .