I-309 ELISA Kit

Storage Instruction:Store the kit at 4°C.
Description:
I-309 is expressed and secreted by monocytes, lymphocytes, endothelial cells, and is constitutively overexpressed by mast cell and adult T-cell leukemias. I-309 expression by adherence-purified monocytes can be induced in the presence of both IgG and LPS . I-309 may  influence pathological processes involved in atherosclerosis, drug resistance, cancer and AIDS. Lipoprotein(a) [Lp(a)] levels are an independent risk factor in atherosclerosis and attraction of circulating monocytes to the vessel wall has been shown to occur during the development of the atherosclerotic plaqu. Endothelial cell production of I-309 can be induced by the apolipoprotein(a) [Apo(a)] portion of Lp(a). Apo(a) treated HUVEC culture supernatants can induce monocyte chemotaxis, and this effect can be abrogated by the inclusion of anti-I-309 or anti-CCR8 neutralizing antibodies.