HRG ELISA Kit

Storage Instruction:Store the kit at 4°C.
Description:
Histidine-rich glycoprotein (HRG) is a 75-kDa protein that exists at relatively high levels in the plasma of many vertebrate species including humans and has been the subject of investigation by a number of laboratories. Although the exact physiological function of HRG is unknown, a number of ligands for the molecule have been identified; these include heme, divalent metal ions , heparin, heparan sulfate , plasminogen , fibrinogen , and thrombospondin . HRG has been proposed to have a modular structure allowing it to bind several ligands independently , and evidence suggests that the interaction of HRG with glycosaminoglycans is regulated by metal ions and pH . HRG also has been found to be a regulator of heparin binding growth factor action , lymphocyte proliferation , and lymphocyte cell adhesion . Recently, we showed that HRG binds strongly to immunoglobulin (IgG) and inhibits the formation of insoluble immune complexes (IICs) between ovalbumin and polyclonal rabbit anti-ovalbumin IgG in vitro .