FGF-2 ELISA Kit

Storage Instruction:Store the kit at 4°C.
Description:
Fibroblast growth factor 2 (FGF2), a member of the FGF family that plays important roles in developmental morphogenic processes, is abnormally elevated in the bone marrow from patients with clonal myeloid disorders and other disorders where normal hematopoiesis is impaired. 
FGF2 is present in bone marrow, but the cell types that produce FGF2 in bone marrow remain undefined. Bone marrow stromal cells,megakaryocytes, and platelets have been reported to contain FGF2. Several studies reported that FGF2 variously modulates hematopoiesis in vitro, and suggested that FGF2 may play a role in normal and pathological hematopoiesis.In long-term bone marrow cultures, FGF2 at low concentrations (0.2-2 ng/mL) increased the number of progenitor cells of myeloid lineage, but the mechanisms underlying this action are not clear.FGF2 stimulated megakaryocytopoiesis in various culture systems, acting indirectly through IL-6, IL-1, or perhaps IL-3. Genetic defects of FGF receptors have been linked to a set of diseases affecting the musculoskeletal system, and deregulated FGF2 has been linked to atherosclerosis. FGF2 is found at abnormally high concentrations in the bone marrow of patients with various clonal chronic myeloproliferative diseases, including myeloid metaplasia with myelofibrosis,which are often associated with reduced bone marrow hematopoiesis, myelofibrosis, release of immature cells to the peripheral blood, and the development of extramedullary hematopoiesis.